Fat grafting is a technique in which harvested adipose tissue is injected underneath the skin to reconstruct traumatic, oncologic, or congenital defects. The technique may also be used for cosmetic purposes, particularly facial rejuvenation. The term “autologous fat grafting” refers to the same procedure when the fat is harvested from the person who will receive it, which is the most common clinical scenario. Autologous fat is considered by many to be the ideal filler material for facial rejuvenation, as it is 100% biocompatible, produces a soft and natural result, and is theoretically a permanent intervention. This activity reviews the utility of this procedure for facial rejuvenation and highlights the role of the interprofessional team in managing and improving care for patients who undergo autologous fat grafting.Fat grafting, also referred to as fat transfer or fat injections, is the surgical process by which fat is transferred from one area of the body to another area. The surgical goal is to improve or augment the area where the fat is injected. The technique involves extracting adipose fat by liposuction, processing the fat, and then reinjecting purified fat into the area needing improvement.